Vari-X-linker UV cross-linker

Information about the Vari-X-linker UV cross-linker

Since 2013 we have been working closely with UVO3, a UK based company, to develop new tools for rapid UV protein-RNA cross-linking in vivo and cell harvesting. We brought it on the market in 2018 and it has already been sold to labs all over the world. For more information about the Vari-X-linker and our rapid cell harvesting system, please visit the following link:


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Relevant publications:

1) Ira A. IosubRob W. van NuesStuart W. McKellarKaren J. Nieken, Marta Marchioretto, Brandon Sy, Jai J. Tree, Gabriella Viero and Sander Granneman.

Hfq CLASH uncovers sRNA-target interaction networks linked to nutrient availability adaptation. eLIFE, 2020;9:e54655 DOI: 10.7554/eLife.54655

2) Stuart W. McKellarIvayla IvanovaRobert W. van NuesRoss A. Cordiner, Will Worboys, Andrew Langford, Torben Heick Jensen and Sander Granneman.

Monitoring Protein-RNA Interaction Dynamics in vivo at High Temporal Resolution Using χCRAC. J. Vis. Exp., 2020; May 9;(159) DOI: 10.3791/61027.

3) Rob van Nues, Gabriele Schweikert, Erica de Leau, Alina Selega, Andrew Langford, Ryan Franklin, Ira Iosub, Peter Wadsworth, Guido Sanguinetti and Sander Granneman#

Kinetic CRAC uncovers a role for Nab3 in determining gene expression profiles during stress.

Nature Communications, 2017; DOI: 10.1038/s41467-017-00025-5