sglab's blog

diffBUM-HMM paper got accepted in Genome Biology!

  • Posted on: 19 May 2021
  • By: sglab

Our paper describing novel algorithms for the detection of RNA structural changes in high-throughput sequencing data has been accepted by Genome Biology!

This project was in close collaboration with Guido Sanguinetti's group and the analyses were performed by two students that at the time were undergraduate students doing internships!

A fantastic result!

Sofia joins the lab!

  • Posted on: 17 March 2021
  • By: sglab

Sofia Esteban Serna joins our lab!

Sofia is a new Wellcome Trust iCM PhD student in our lab and her project involves understanding the role of RNA-binding proteins in tight regulation of gene expression.

When some genes are expressed at too high levels it can be toxic to the cell. We found a mechanisn that involves RNA-binding proteins that suppresses this overshooting and keeps tight control of expression of some stress-responsive genes.

Sofia's goal will be to dissect this mechanism and understand how it contributes to stress adaptation.

Our Hfq CLASH paper got accepted for publication in eLIFE!

  • Posted on: 30 April 2020
  • By: sglab

My former PhD student Ira Iosub spent about four years working on a project to identify Hfq-mediated sRNA-target interactions.

Her reasearch has unearthed a plethora of novel sRNA-mRNA interactions as well as many sRNA-sRNA interactions that potentiall connect many different metabolic pathways.

Consistent with recent work from Hannah Margalit's lab, we found that sRNA-mRNA interactions that are reproducibly detected are more likely to impact steady state levels of their mRNA targets.

This work was done in collaboration with the labs of Jai Tree and Gabriella Viero!