Our Nature Communications RNA structure probing paper is now online!!
After 4 years of hard graft and overcoming many technical and computational challenges our pre-60S RNA structure probing paper is now online on the Nature Communications website! The first author is Elena Burlacu, a former PhD student from my lab. We have mapped the structural changes that take place during early 60S assembly and could show that folding of some regions in the 60S pre-rRNA takes place at very specific stages of maturation. We also make predictions about long-range interactions that form during nucleolar stages of assembly and performed a comprehensive analysis of ITS2 structure.
This work was done in collaboration with the Oeffinger, Wieslander and Cockroft labs! A fantastic result!