In collaboration with Guido Sanguinetti’s group we developed new statistical algorithms for calling modified nucleotides in high-throughput RNA structure probing data. These new tools greatly increase the sensitivity of RNA structure probing methods, even at low coverage. The next challenge is to modify this method so that we can use it to determine which nucleotides undergo conformational changes under different conditions or during assembly of large macromolecular complexes, such as the ribosome. Can’t wait!!
The lab has been collaborating with Ross Fitzgerald’s group at the Roslin Institute in Edinburgh for a while now to study RNA-binding proteins in nasty bugs. Now that I am an associate scientist at Roslin, we will be able to interact with many experts in infection and immunity and we will have access to the amazing facilities at the institute! This should greatly benefit our research and will help us to expand into new and exciting research areas.
Stuart McKellar, a Wellcome-Trust funded PhD student, has decided to join my lab to work on some very nasty bugs! This work, in collaboration with Ross Fitzgerald’s group in Roslin and Jai Tree in Sydney, promises to unravel new layers and mechanisms of gene regulation in nasty bacteria!
Karen Julia (aka Jule) is a summer student from Germany that decided to join our lab to help Ira out with her projects.
All I can say is that it has something to do with pores!
Sander was extremely pleased to hear that he was awarded the 2015 School of Biological Sciences Recognizing Excellence award; Knowledge Exchange and Commercialization.
This award was given as a recognition for his work on protein-RNA interactions and the impact it had on many RNA groups in the School. The Granneman lab has been collaborating closely with its industrial partner (UVO3) for many years and this has resulted in the development of several UV cross-linking machines that have been sold all over the world.