My lab is interested in the role of RNA structure and RNA binding proteins in the regulation of gene expression. Most of our research has focussed on the assembly of large macromolecular complexes, such as the yeast ribosome. However, more recently, we have also been working on understanding the role of RNA surveillance factors in the regulation of mRNA transcription and translation in both yeast and pathogenic bacteria. The goal of our research is to obtain detailed mechanistic insights into the strategies that organisms use for regulating ribonucleoprotein assembly and mRNA synthesis. For our research we use highly innovative methodologies such as CRAC and CLASH and high-throughput structure probing methods. Our work is funded by the BBSRC, SULSA and the Wellcome Trust.


Sander Granneman, PhD

Wellcome Trust RCD Fellow

University of Edinburgh

Institute of Structural and Molecular Biology

Centre for Synthetic and Systems Biology (SynthSys)

University of Edinburgh

Max Born Crescent                                                                 

CH Waddington Building, room 3.06



e-mail: sgrannem@staffmail.ed.ac.uk


office: +44 (0) 131 651 9082

lab:+44 (0) 131 651 9055